East of Fresno in the Sequoia National Park, the 72 mile High Sierra Trail is a classic hiking trek across Sequoia National Park from west to east past giant sequoia groves and through canyons and passes.
To reach the western trailhead, follow Generals Highway in Giant Forest. Turn onto Cresent Meadow Road for 3.5 miles to the trailhead.
To reach the eastern trailhead, head 13 miles west of Lone Pine to Whitney Portal.
Overall, High Sierra Trail is the 36th most popular hiking trail of all 88 hikes in California.