Near Manchester, the Pennine Way is a 268 mile trek from Edale in the Peak District National Park north to Kirk Yetholm on the Scottish border. The route follows a limestone ridgrline and rolls over numerous treeless grassy hills known as fells. Luckily, camping is not permitted along the way, so you will have to enjoy one of four huts (bothies) and the numerous inns near the route.
Typically, the route is hiked from the south to the north to keep the wind at your back. The southern terminus can be reached from Manchester by taking the Transpeak bus for 17 miles to the Derbyshire stop. On the northern end, plan on stopping at the Border Hotel in Kirk Yetholm.
Overall, Pennine Way is the 16th most popular hiking trail of all 16 hikes in UK.